The client is seeking an external expert who brings a decision-maker’s mindset — someone who has personally driven translational pharmacology choices under governance and uncertainty.
Who we’re looking for
Has owned FIH starting dose, SAD/MAD design, and Phase 2 dose selection for multiple assets.
Participated in governance or review boards, defending dose/exposure rationale in front of senior leadership or regulators.
Demonstrates ability to balance nonclinical → clinical translation : tox, PK, PD, potency, and MoA.
Can articulate the real decision calculus behind dose selection (safety, pharmacology, speed-to-proof).
Capable of turning narrative judgment into explicit decision rules and rubrics for AI training and evaluation.
Experience level
~10+ years in major biopharma or biotech (e.g., Lilly, Roche, AbbVie, Amgen, Novartis, GSK, Regeneron, Vertex, Incyte, Gilead) or in specialized translational pharmacology consulting.
Has personally led FIH dose and/or SAD/MAD escalation for ≥2–3 assets.
Proven governance experience: IND sign-off, dose justification memos, exposure–response presentations.
CV or track record includes statements like “led clinical pharmacology strategy and FIH dose selection” or “accountable for exposure–response in Phase 1/2.”
Avoid pure modeling profiles; the ideal expert has decision accountability , not just analytical skill.
Expectations
Write “golden” FIH dose rationales and escalation strategies for representative programs.
Encode the decision heuristics and trade-offs used by senior translational leaders into structured guidance and rubrics.
Surface unwritten decision rules — when and why experienced teams override model-based recommendations.
Inputs given:
Representative drug programs or data packets (GLP tox summaries, PK/PD tables, potency & MoA context).
Target prompts for translational decision-making (e.g., “Recommend FIH dose and escalation strategy given these data”).
Expected outputs:
Golden Decision Memos: exemplar dose justification memos that reflect the level of reasoning and format expected from top-tier translational pharmacologists.
Decision Rubrics: scoring guides capturing acceptable vs. unsafe dose rationales, missed edge cases, or failure modes.
Meta-Layer Commentary: short narrative explaining unspoken heuristics — how senior teams weigh risk tolerance, potency data, or tox uncertainty.
...Right now Domino's is looking for qualified drivers to staff stores in your area.We're... ...Franchise Owners started in management training, delivery or answering phones. Apply now to get the... ...Information Hiring for weekdays, nights and weekends from 10:30am until 10pm...
...fellow staff. Please reply to this posting or come by the campus location to complete an application.2805 Charles Bryan Road Bartlett, TN 38134.Job Type: Full-timeSchedule:* Evening shift* Night shift* Rotating weekendsWork Location: In person
Summary Description Positions in this class are assigned to the local school to assist the administration maintain a safe and secure learning environment for the school community. Under the general supervision of the security team leader, assists in screening visitor...
...the business in 1975. Eight years later, I joined him as an apprentice electrician. For almost four decades, we focused primarily on... ...growing home service companies in Alabama! We are hiring plumbers, HVAC technicians and electricians, administrative staff and more....
...Join our Laboratory Services team providing excellent patientcare with a skilled team of providers! We offer a team approach to healthcare... ...science-related field with completion of asix-month clinical internship from a National Accrediting Agency for ClinicalLaboratory...